Development of biotin prototrophic and hyper - auxotrophic 2 Corynebacterium glutamicum strains toward biotin production
نویسندگان
چکیده
1 Development of biotin prototrophic and hyper-auxotrophic 2 Corynebacterium glutamicum strains toward biotin production 3 4 Running title: Engineering of C. glutamicum biotin auxotrophy 5 6 Masato Ikeda,* Aya Miyamoto, Sumire Mutoh, Yuko Kitano, a Mei Tajima, a Daisuke 7 Shirakura, Manami Takasaki, Satoshi Mitsuhashi, and Seiki Takeno 8 9 Department of Bioscience and Biotechnology, Faculty of Agriculture 10 Shinshu University, Nagano 399-4598, Japan, and 11 Bioprocess Development Center, Kyowa Hakko Bio Co., Ltd., 12 Tsukuba, Ibaraki 305-0841, Japan 13 14 15 16 17 *Corresponding author: Mailing address: Department of Bioscience and 18 Biotechnology, Faculty of Agriculture, Shinshu University, Nagano 399-4598, Japan 19 Phone: +81-265-77-1614. Fax: +81-265-77-1629. E-mail: [email protected] 20 21
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